Gene information
Official symbol PLG
Official full name plasminogen
Gene type protein-coding gene
Chromosome6q26
Resources
Entrez Gene 5340
HGNC HGNC:9071
Ensembl ENSG00000122194
Vega OTTHUMG00000015957
UCSC uc003qtm.5
GO terms: 83 records
GO Description Category LogP Number of genes Detail
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0001892 embryonic placenta development GO Biological Processes -3.02613520 11 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0003823 antigen binding GO Molecular Functions -1.57341070 6 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010812 negative regulation of cell-substrate adhesion GO Biological Processes -8.89322529 17 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019898 extrinsic component of membrane GO Cellular Components -2.13392265 23 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042246 tissue regeneration GO Biological Processes -5.28671514 12 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045445 myoblast differentiation GO Biological Processes -2.24389415 5 More
GO:0046716 muscle cell cellular homeostasis GO Biological Processes -3.83961894 4 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051087 chaperone binding GO Molecular Functions -6.81600949 11 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051918 negative regulation of fibrinolysis GO Biological Processes -14.1555780 9 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0060711 labyrinthine layer development GO Biological Processes -3.15848951 8 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0098685 Schaffer collateral - CA1 synapse GO Cellular Components -5.81792293 14 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
Drug-Gene interaction
view
Related drugs: 29 records
Drug name Interaction type Source PMID View
alteplase activator TdgClinicalTrialChemblInteractionsNCITENDTTD 1203392011752352194366561867323517963464 view
amediplase TdgClinicalTrial view
aminocaproic acid inhibitor ChemblInteractions view
anistreplase activator TdgClinicalTrialTENDTTD 11752352194366561867323517963464 view
aprotinin inhibitor ChemblInteractions 15277296 view
bortezomib DTC 20875739 view
chembl35482 NCI 15613028 view
coumarin NCI 3160707 view
danazol NCI 852977131466157607583 view
defibrotide sodium activator ChemblInteractions view
desmoteplase activator TdgClinicalTrialChemblInteractionsTTD 17425487 view
fibrinolysin, human TdgClinicalTrial view
garlic NCI 17213677 view
genistein NCI 11835393 view
human growth hormone NCI 157606702143511 view
inositol NCI 1648562 view
lepirudin NCI 15894352 view
melagatran TTD view
norethindrone NCI 1442974 view
nystatin NCI 7721938 view
oxymetholone NCI 3238652 view
prednisolone NCI 2079995 view
radiosumin b DTC 11374973 view
ranolazine TTD view
reteplase activator TdgClinicalTrialChemblInteractionsTENDTTD 11752352194366561867323517963464 view
streptokinase activator TdgClinicalTrialChemblInteractionsTENDTTD 105819961066458310726310117523521063199710569766 view
tenecteplase activator TdgClinicalTrialChemblInteractionsTENDTTD 11752352194366561867323517963464 view
tranexamic acid inhibitor ChemblInteractions view
urokinase activator TdgClinicalTrialChemblInteractionsTEND 127203001265877412745435117523521271977812666133 view
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
plasminogen proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Moreno JA et al. Sangre (Barc). 1994
plasmin-antiplasmin complex proteomics myocardial infarction[diagnosis] myocardial infarction Cushman M et al. Arterioscler Thromb Vasc Biol. 1999
plasmin-antiplasmin complex proteomics major adverse cardiovascular events[prognosis (bad)] myocardial infarction Redondo M et al. Blood Coagul Fibrinolysis. 2001
plasmin-antiplasmin complex proteomics infarct-related artery patency[prognosis (good)] acute ST elevation myocardial infarction Huisse MG et al. Thromb Haemost. 2007
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